Wolfgang Bogner, PhD

Info

I am a passionate developer of new MR imaging techniques, in particular at ultra-high magnetic field strength (7T). My interests covers anything from designing and programming a new MR sequence over careful testing at the MR scanner, evaluations in volunteer scans, and clinical translation. There is nothing better than watching the full scientific and clinical potential of one of our new MRI methods unfold.

Currently my team is focusing on the development and clinical translation of advanced Molecular MRI techniques. This includes in particular MR spectroscopic imaging (MRSI) and more recently related techniques such as chemical exchange saturation transfer (CEST), but also Diffusion weighted imaging and X-nuclei MRI in general. I have a fair share of expertise in a large variety of image acquisition and image/data processing techniques: RF pulse design, imaging acceleration (rapid k-space trajectory design, coherent and incoherent undersampling, prior knowledge reconstruction), real-time motion and hardware instability correction, dynamic scanner (e.g., B0) updating, coil combination, quantum-mechanical simulations, quantitative MRI (e.g., MR fingerprinting) and deep learning in MRI reconstruction.

While I do of course as a physicist enjoy technical development, I am equally excited to watch our new methods being applied in different patient studies. Therefore, we are currently performing several patient studies involving neurological diseases (e.g., Parkinson, Multiple Sclerosis), oncologic topics (e.g., brain tumor, breast cancer), various metabolic disorders (e.g., orphan diseases), and most recently psychiatric disorders (e.g., Schizophrenia).

Don’t hesitate to contact me, if you are interested in scientific collaboration or joining our team.

Team

I am fortunate to have an excellent team of ambitious researchers. Their continued dedication and hard work have made our recent groundbreaking achievements possible.

PostDocs:

• Bernhard Strasser (exchange stipend – Martinos Center, Boston until June 2020)
• Gilbert Hangel (50% position at Neurosurgery, Intraoperative MRI)
• Petr Bednarik
• Philipp Moser
• Eva Heckova

PhD students:

• Lukas Hingerl
• Alexandra Lipka
• Stanislav Motyka
• Esau Poblador Rodriguez
• Verena Endmayr (jointly with Neuropathology, team S.Hametner)
• Benjamin Spurny (co-supervised, team R. Lanzenberger)

Master’s students:

• Tobias Klein
• Dario Goranovic
• Philipp Lazen

5 selected projects

• FWF project KLI 718, Myo-Inositol–new imaging biomarker for Multiple Sclerosis, 2018-2022 (Principal Investigator, 408k€)
• FWF project, P30701, 3D spectroscopic imaging with ultra-short acquisition delay, 2018-2021 (Principal Investigator, 400k€)
• FFG Bridge project #846505, Imaging oxidative stress via in vivo quantification of glutathione, 2015-2017 (Principal Investigator, 480k€)
• Christian Doppler Laboratory on Clinical molecular MR imaging (MOLIMA), 2015-2021 (1.5Mio€; I am Coordinator of WP3: ¹H-MR spectroscopic imaging)
• Austrian National Bank project #16133, Mapping aberrant myocardial creatine kinase metabolism via frequency labeled exchange transfer, 2015-2017 (Principal Investigator, 190k€)

5 selected publications

• W.Bogner, S.Gruber, K.Pinker, G.Grabner, A.Stadlbauer, M.Weber, E.Moser, T.Helbich, S.Trattnig: Diffusion-weighted MRI for differentiation of breast lesions at 3.0 Tesla: How does selection of diffusion schemes affect diagnosis? Radiology Nov 2009; 253(2): 341-51
• W.Bogner, K.Pinker-Domenig, H.Bickel, M.Chmelik, M.Weber, T.H.Helbich, S.Trattnig, S.Gruber: 3D Readout-segmented echo-planar imaging improves the diagnostic performance of diffusion-weighted MR breast examinations at 3.0 T. Radiology 2010 263 (1), 64-76
• W.Bogner, S Gruber, M Doelken, A Stadlbauer, O Ganslandt, U Boettcher, S Trattnig, A Doerfler, H Stefan, T Hammen: In vivo quantification of intracerebral GABA by single-voxel 1H-MRS. European Radiology Mar 2010; 73 (3), 526-531
• W.Bogner, B.Gagoski, A.T. Hess, H.Bhat, M.D.Tisdall, A. J.W. van der Kouwe, B.Strasser, S.Trattnig, E.Grant, B.Rosen, O.C.Andronesi: 3D GABA imaging with real-time motion correction, shim update and reacquisition of adiabatic spiral MRSI. Neuroimage Dec 2014; 103:290-302
• G.Hangel, B.Strasser, M.Povazan, E.Heckova, L.Hingerl, R.Boubela, S.Gruber, S.Trattnig, W.Bogner: Ultra-high-resolution brain metabolite mapping at 7 T by short-TR Hadamard-encoded FID-MRSI. Neuroimage Mar 2018; 168:199-210

5 selected invited talks

• Invited talk “Towards in vivo whole-brain neurochemical fingerprinting at ultra-high field” ENC conference on NMR 2020 (Baltimore)
• Invited talk “Advanced UHF Spectroscopy in Biomarker Discovery” ISMRM Workshop on Ultra-High-Field Magnetic Resonance 2019 (Dubrovnik)
• Invited talk “Parallel Imaging & Spatial-Spectral Encoding Accelerated FID-MRSI at 7T” ISMRM – MIS on Breaking the Spatiotemporal Limits of MRSI 2018 (Paris)
• Invited talk Advanced MRS in Operation: “Applications of Spectral Editing” ISMRM 2016 (Singapore)
• Invited talk “GRAPPA and Multi-Band MRSI” ISMRM workshop on MRS 2016 (Konstanz)

Collaboration partners

external

• Ovidiu C. Andronesi (Martinos Center, Harvard Medical School, Boston)
• Andre.v.d.Kouwe (Martinos Center, Harvard Medical School, Boston)
• Simon D. Robinson (Center for Advanced Imaging, Univ. Queensland, Brisbane)
• Ladislav Valkovic (Radcliffe Dept. of Medicine, Univ. of Oxford)
• Benedikt Poser (Psychology and Neuroscience, Maastricht University, Maastricht)
• Michal Povazan (Dept. Radiology and Radiological Science, Johns Hopkins Univ. Baltimore)
• Martin Gajdosik (MR Science Lab, Columbia University, New York)
• Barbara Dymerska (Department of Medical Physics and Bioengineering, UCL, London)

internal

• Rupert Lanzenberger (Neuroimaging Labs, Medical Univ. Vienna)
• Georg Langs (Computational Imaging Research Lab, Medical Univ. Vienna)
• Maxim Zaitsev (High-field MR Center, Dept. CMPBE, Medical Univ. Vienna)
• Siegfried Trattnig (High-field MR Center, Dept. Biomedical Imaging, Medical Univ. Vienna)
• Stephan Gruber (High-field MR Center, Dept. Biomedical Imaging, Medical Univ. Vienna)
• Martin Krssak (High-field MR Center, Internal Medicine III, Medical Univ. Vienna)
• Simon Hametner (Center for Brain Research, Medical Univ. Vienna)
• Assunta Dal-Bianco (Neurology, Medical Univ. Vienna)
• Hans Lassmann (Center for Brain Research, Medical Univ. Vienna)
• Georg Dorfner (Institute of Artificial Intelligence, Medical Univ. Vienna)

Member of Clusters

• Medical Imaging Cluster
• Neuroscience Cluster
• Comprehensive Cancer Center